[edited from support email]
Another case:

When I run the sample1 data file according to the online tutorial, I get this error message 3050 couldn't lock file.
Did you confirm read/write access? An easy way to tell if that's it is to run it as an Admin--if it then works, the trouble is usually read/write permission. Can you try a second machine to see if the error replicates?

Once the permissions were changed on the Media Lab folder, the application functioned as expected.